Gjumrakch Aliev
President, GALLY International Biomedical Research Institute Inc, USA
Title: Alternative Strategies for Drug Delivery to the Brain: Recent Challenges
Biography
Biography: Gjumrakch Aliev
Abstract
According to statistical reports by well-known authentic centers such as Centre for Disease Control and Prevention, as well as the National Centre for Health, Alzheimer disease (AD) has surpassed cardiovascular, diabetes, and cancer as a leading cause of death. AD, the most common form of dementia, is an exasperating health disorder characterized by a progressive decline in cognitive function. One of the biggest problems and challenges for the development of new drugs and treatment strategies against different type of the cancer and AD is the crossing of target drugs the blood brain barrier. The use of nanoparticles in drug delivery therapy holds much promise in targeting remote tissues, and as a result many studies have attempted to study the ultrastructural localization of nanoparticles in various tissues. However, there are currently no in vivo studies demonstrating the ultrastructural distribution of nanoparticles in the brain. The aim of this study was to address how intraperitoneal injection of silver nanoparticles in the brain leads to leaking on the inter-endothelial contact and luminal plasma membrane, thus elucidating the possibility of penetrating into the most affected areas in the cancer and Alzheimer brain (vascular endothelium, perivascular, neuronal and glial cells). Our results show that the silver nanoparticles reached the brain and were found in hippocampal areas, indicating that they can be conjugated and used to deliver the drugs into the cell cytoplasm of the damaged brain cells. The present study can be useful for the development of novel drug delivering therapy and useful in understanding the delivery, distribution and effects of silver nanoparticles in cancer and AD brain tissue at cellular and subcellular level.