Yu-Sheng Liu
The Second Hospital of Shandong University, China
Title: Sitagliptin Alleviated Myocardial Remodeling of Left Ventricle and Improved Cardiac Diastolic Dysfunction in Diabetic Rats
Biography
Biography: Yu-Sheng Liu
Abstract
OBJECTIVE Sitagliptin as one of DPP-â…£ inhibitors plays its biological role via improving the serum levels of GLP-1. Hence, we sought to determine the effects of sitagliptin on myocardial inflammation, collagen metabolism, lipids content and myocardial apoptosis in diabetic rats. METHODS The type 2 diabetic models were induced by small dosage streptozotocin on the basis of high-fat diet. The characteristics of the diabetic rats were evaluated by ECG, echocardiography and blood analysis. Cardiac inflammation, ï¬brosis, cardiomyocyte density, lipids accumulation, and RIP3 related to apoptosis were detected by histopathologic analysis, RT-PCR and Western-blot analysis to evaluate the effects of sitagliptin on myocardial remodeling of left ventricle. RESULTS Myocardial hypertrophy or apoptosis, inflammation, lipids accumulation, myocardial ï¬brosis, elevated collagen contents, RIP3 overexpression, and left ventricular dysfunction were detected in diabetic rats. Furthermore, sitagliptin could down-regulate the overexpression of RIP3 and alleviate cellular apoptosis in the myocardial tissues. Sitagliptin could significantly improve left ventricular systolic pressure (LVSP), +dp/dt max, reduce the E/E＇ratio, left ventricular end diastolic pressure (LVEDP), -dp/dt max and Tau in diabetic rats. CONCLUSIONS Sitagliptin might exert a myocardial protective effect by inhibiting apoptosis, inflammation, lipids accumulation and myocardial ï¬brosis, implicating its potential role for the improvement of left ventricular function.