Rama Swamy Nanna
Kakatiya University, India
Title: Screening of pharmacological activities of aqueous leaf extracts of Senna alata using animal models
Biography
Biography: Rama Swamy Nanna
Abstract
Medicinal plants are being used in herbal remedies and healthcare preparations since the beginning of the survival of manhood. Apart from being the source of medicine, they are also being used as food and fodder and other valuable compounds that are playing a healthy role in human existence and also contributing to the uplifting nation’s economy and social and cultural benefits. The species Senna alata L. Roxb, commonly known as Ringworm Senna or Candle Brush Tree or Seven Golden Candle Sticks is an important medicinal and ornamental plant belonging to Fabaceae family. A set of pharmacological parameters of aqueous leaf extracts of the species was investigated using various animal models. Anti-diabetic activity of aqueous leaf extracts of S. alata has been carried out using alloxan induced diabetes in rats and the hyperlipedemic profile associated with diabetes was also tested. A decrease in all the parameters (fasting glucose levels and post treatment blood glucose levels) associated with diabetes were decreased upon administration of the test drug (200 mg/kg) for 2 weeks. The anti-hyperglycemic effect of S. alata on post treated blood glucose levels in the diabetic rats was assessed on 1st, 7th and 15th day. There was also a decrease in the hyper lipidemic profile associated with diabetes, i.e., total cholesterol, HDL, LDL and triglyceride levels in the test group in comparison with the diabetic control group on the 15th day in alloxan induced diabetic rats. Antidepressant activity of aqueous leaf extracts of S. alata was carried out using forced swim test and tail suspension test. Anti-anxiety activity of aqueous leaf extracts of S. alata has also been studied by elevated plus maze test in rats. Anti-angiogenesis activity of aqueous and methanolic leaf extracts of S. alata was also carried out separately by chicken CAM assay. According to our observations the bioactive molecules present in the leaf extracts of S. alata showed ethno-medicinal properties