Zhang Li
Shanghai University of Traditional Chinese Medicine, China
Title: Identification and mechanism study of novel anti-cancer components from Garcinia species
Biography
Biography: Zhang Li
Abstract
The Garcinia genus is an invaluable source of novel bioactive compounds. Of the 20 Garcinia spp. found across China, over 300 compounds including 90 novel xanthones and PPAPs from 15 such plants have been identified by our group. It is intriguing to find that xanthones and PPAPs possess discrete anti-cancer properties not limited to cell cycle arrest, apoptosis, autophagy and anti-metastasis. In this presentation, we will summarize our systematic work in the last 10 years including: (1) the bioassay-guided fractionation and identification of novel compounds from Garcinia plants; (2) the mechanism study of active compounds targeting multiple pathways such as apoptosis, autophagy, and metastasis; (3) the evaluation of synergistic effects of combinations of various lead compounds with anti-cancer drugs. The understanding of synergistic effects of isolated active compounds can be an imperative approach for finding new efficient drugs in the treatment of cancer. Our studies provide scientific evidences supporting further research and development of the promising lead compounds identified from Garcinia species in China.