Md. Mahbubur Rahman.
KNOTUS (Ex. Korean Animal Medical Science Institute), South Korea
Title: Antidiabetic Effects of Yam (Dioscorea batatas) and its Active Constituent, Allantoin, in a Rat Model of Streptozotocin-induced Diabetes
Biography
Biography: Md. Mahbubur Rahman.
Abstract
The objective of this study was to investigate the therapeutic efficacies of crude yam (Dioscorea batatas) powder (PY), water extract of yam (EY), and allantoin (the active constituent of yam) in streptozotocin (STZ)-induced diabetic rats with respect to glucose, insulin, glucagon-like peptide-1 (GLP-1), C-peptide, glycated hemoglobin (HbAlc), lipid metabolism, and oxidative stress. For this purpose, 50 rats were divided into five groups: normal control (NC), diabetic control (STZ), and STZ plus treatment groups (STZ + PY, STZ + EY, and STZ + allantoin). After treatment for one-month, there was a decrease in blood glucose: 385 ± 7 in STZ, 231 ± 3 in STZ + PY, 214 ± 11 in STZ + EY, and 243 ± 6 mg/dL in STZ + allantoin, respectively which were significant statistical differences (p < 0.001) compared to STZ. With groups in the same order, there were significant decreases (p < 0.001) in HbAlc, total cholesterol and low-density lipoprotein. There were also significant increases (p < 0.001) in insulin, GLP-1, and C-peptide. The treatment effectively ameliorated antioxidant stress as shown by a significant decrease (p < 0.001) in malondialdehyde together with increases (p < 0.01) in superoxide dismutase and reduced glutathione. The results indicate that yam and allantoin have antidiabetic effects by modulating antioxidant activities, lipid profiles and by promoting the release of GLP-1, thereby improving the function of β-cells maintaining normal insulin and glucose levels