11^th International Conference and Exhibition on Pharmacology and Ethnopharmacology July 18-19, 2018 Atlanta, Georgia, USA

Pharmacology is the branch of science worried with the investigation of medication action, where a medication can be extensively characterized as any man-made, characteristic, or endogenous (from inside body) atom which applies a biochemical and additionally physiological impact on the cell, tissue, organ, or living being (some of the time the word pharmacon is utilized as a term to envelop these endogenous and exogenous bioactive species). All the more particularly, it is the investigation of the associations that happen between a living life form and chemicals that influence typical or anomalous biochemical capacity. In the event that substances have therapeutic properties, they are considered pharmaceuticals.

Pharmacology of vascular endothelium deals with alterations of endothelial cells and the vasculature play a central role in the pathogenesis of a broad spectrum of the most dreadful of human diseases, as endothelial cells have the key function of participating in the maintenance of patent and functional capillaries.

This market is expected to increase from nearly $17.1 billion in 2015 to $23 billion by 2020, with a compound annual growth rate (CAGR) of 6.1% from 2015 to 2020.

Ethnopharmacology is a study or comparison of the traditional medicine practiced by various ethnic groups, and especially by indigenous peoples. The word ethnomedicine is sometimes used as a synonym for traditional medicine. Ethnomedical research is interdisciplinary; in its study of traditional medicines, it applies the methods of ethnobotany and medical anthropology. Often, the medicine traditions it studies are preserved only by oral tradition.

Scientific ethnomedical studies constitute either anthropological research or drug discovery research. Anthropological studies examine the cultural perception and context of a traditional medicine. The purpose of drug discovery research is to identify and develop a marketable pharmaceutical product.

Pharmacognosy is the study of medicines or crude drugs produced from natural sources such as plants, microbes, and animals. It includes analysis of their biological, chemical, biochemical, and physical properties. The renaissance of herbal medicine in this country creates a demand for studies in the field of Pharmacognosy. From a practical perspective this includes:

• quality control (identity, purity, consistency)
• efficacy (therapeutic indications, clinical studies, pharmacological investigations)
• safety (adverse reactions, drug interactions, contraindications, precautions)

The investigation of biological and chemical properties of natural products for the past two centuries has not only produced drugs for the treatment of several diseases, but has instigated the development of synthetic organic chemistry and the arrival of medicinal chemistry as a major route to discover efficacious and novel therapeutic agents. Structural alteration of natural compounds or synthesis of novel compounds, based on designs following a natural compound scaffolding, have offered us a lot of vital new drugs in the fields of medicine, agriculture, and food spheres. Nature has provided a fascinating array of chemical structures in the form of bioactive secondary metabolites.

Traditional Chinese medicine (TCM) originated in ancient China and has evolved over thousands of years. TCM practitioners use herbal medicines and various mind and body practices, such as acupuncture and tai chi, to treat or prevent health problems. In the United States, people use TCM primarily as a complementary health approach.

TCM encompasses many different practices, including acupuncture, moxibustion (burning an herb above the skin to apply heat to acupuncture points), Chinese herbal medicine, tui na (Chinese therapeutic massage), dietary therapy, and tai chi and qi gong (practices that combine specific movements or postures, coordinated breathing, and mental focus)

Herbal medicine, also called botanical medicine or phytomedicine, refers to using a plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Herbalism has a long tradition of use outside conventional medicine. It is becoming more mainstream as improvements in analysis and quality control, along with advances in clinical research, show the value of herbal medicine in treating and preventing disease.

Holistic medicine is a system of health care which fosters a cooperative relationship among all those involved, leading towards optimal attainment of the physical, mental emotional, social and spiritual aspects of health. It emphasizes the need to look at the whole person, including analysis of physical, nutritional, environmental, emotional, social, spiritual and lifestyle values. It encompasses all stated modalities of diagnosis and treatment including drugs and surgery if no safe alternative exists. Holistic medicine focuses on education and responsibility for personal efforts to achieve balance and well-being.

Pharmacokinetic and Pharmacodynamic parameters become important because of the association between host drug concentrations, microorganism eradication, and resistance.Since long scientific advances allowed scientists to come together with the study of physiological effects with biological effects.

The Pharmaceutical industry's long successful strategy of placing big bets on a few molecules, promoting them heavily and turning them into blockbusters worked well for many years, but its R&D productivity has now plummeted and the environment’s changing.Drug biotransformation reactions

The plant kingdom is a treasure house of potential drugs and in the recent years there has been an increasing awareness about the importance of medicinal plants. Drugs from the plants are easily available, less expensive, safe, and efficient and rarely have side effects. The plants which have been selected for medicinal use over thousands of years constitute the most obvious choice of examining the current search for therapeutically effective new drugs such as anticancer drugs antimicrobial drugs anti hepatotoxic compounds.

According to World Health Organization (WHO), medicinal plants would be the best source to obtain variety of drugs. About 80% of individuals from developed countries use traditional medicines, which has compounds derived from medicinal plants. However, such plants should be investigated to better understand their properties, safety, and efficiency.  Medicinal plants contain some organic compounds which provide definite physiological action on the human body and these bioactive substances include tannins, alkaloids, carbohydrates, terpenoids, steroids and flavonoids. These compounds are synthesized by primary or rather secondary metabolism of living organisms. Secondary metabolites are chemically and taxonomically extremely diverse compounds with obscure function. They are widely used in the human therapy, veterinary, agriculture, scientific research and countless other areas.

Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with drug design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs).Drug Discovery is the identification of novel active chemical compounds, often called "hits", which are typically found by assay of compounds for a desired biological activity.